Our Research Mission

The Spastic Paraplegia Foundation, Inc. (SPF) is the only organization in the Americas dedicated to finding a cure for Hereditary Spastic Paraplegia (HSP) and Primary Lateral Sclerosis (PLS), two closely related upper motor neuron disorders. We are a not-for-profit voluntary organization.

Our primary goal has been to raise money to find a cure. Since our creation in 2002, we have raised and funded over $2 Million in research grants – with notable successes. The conditions are finally much better understood. Last year, researchers have begun to try to stop the action of genes that create spasticity in individuals.

To find out more about our foundation and its research: