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The SPF Community Comes Together for the 23rd HSP/PLS Annual Conference in St. Louis, June 15-17th!  LEARN MORE

Welcome to Spastic Paraplegia Foundation, Inc.

The Spastic Paraplegia Foundation is dedicated to advancing research and finding cures for two groups of closely related, rare, and progressive neurological disorders. They are Hereditary Spastic Paraplegia (HSP) and Primary Lateral Sclerosis (PLS). These are neurological disorders affecting the voluntary muscles. The disorders are progressive and may lead to patients being unable to walk, and more.

  • Linda Lafontaine
    Linda Lafontaine

    I've been dealing with HSP for a very long time. Then I joined a support group and I found the Spastic Paraplegia Foundation. Hopefully I can spread awareness and get others to join the Foundation.

Our Impact Since Inception


SPF Vision

The day when all individuals with HSP or PLS are diagnosed, treated, and cured.


SPF Mission

The Spastic Paraplegia Foundation is committed to funding medical research to find cures for Hereditary Spastic Paraplegia and Primary Lateral Sclerosis, to educate people affected by these conditions with the latest in medical research and treatment options, and to help those affected live full and productive lives.


What's New?


Thank you to our generous sponsors:

  • Cadense
    Cadense
  • Anonymous Donors
    Anonymous Donors
  • Whirlybird
    Whirlybird
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